Cardiac Myosin Heavy Chain Antibodies

Target Information

Cardiac Myosin Heavy Chain (MHC) is a crucial component of the contractile machinery in heart muscle cells. It primarily forms part of the thick filament in sarcomeres, the fundamental units of muscle contraction. The cardiac myosin heavy chain comes in two isoforms, alpha-MHC and beta-MHC, which are encoded by the MYH6 and MYH7 genes, respectively. The alpha-MHC isoform is predominant in the atria and is characterized by faster ATPase activity and contraction speed, whereas the beta-MHC isoform is predominant in the ventricles and is associated with greater endurance. Each myosin molecule consists of two heavy chains, two essential light chains (ELC), and two regulatory light chains (RLC). The heavy chains have distinct functional regions: the globular head, which binds to actin and hydrolyzes ATP to produce force, and the helical tail, which organizes into the thick filament backbone. Mutations in cardiac MHC can lead to various cardiomyopathies, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), both of which significantly affect the heart’s functionality. These disorders underscore the importance of MHC in maintaining normal cardiac physiology and highlight its complex regulation and mechanotransduction capabilities.

Synonyms

A830009F23Rik; AA517445; alpha cardiac MHC; alpha myosin; alpha-cardiac myosin heavy chain; alpha-MHC; alpha-myosin; alpha-myosin heavy chain; alpha-myosin heavy chain subfragment 2 exon; antigen MLAA-21; ASD3; beta cardiac myosin heavy chain; beta myosin heavy chain; beta-MHC; beta-myosin; beta-myosin heavy chain; B-MHC; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain alpha isoform; cardiac myosin heavy chain beta isoform; cardiomyopathy, hypertrophic 1; CMD1EE; CMD1S; CMH1; CMH14; KIAA1512; LOC100736765; LOW QUALITY PROTEIN: myosin-6; LOW QUALITY PROTEIN: myosin-7B; MHC14; MPD1; Myh14; MYH6; MYH7; Myh7b; MYH-beta/slow; MYHC; Myhca; Myhc-a; MyHC-alpha; MYHCB; Myhc-b; MyHC-beta; MyHC-I; MyHC-slow; myopathy, distal 1; myosin alpha heavy chain; Myosin cardiac muscle beta chain; myosin heavy chain; myosin heavy chain 6; Myosin heavy chain 7; myosin heavy chain 7B; myosin heavy chain 7B, cardiac muscle beta isoform; myosin heavy chain polypeptide 6 cardiac muscle adult; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain slow; myosin heavy chain slow isoform; myosin heavy chain slow type 1 (beta cardiac); myosin heavy chain, cardiac; myosin heavy chain, cardiac muscle alpha isoform; Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha); myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, adult; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 6, cardiac muscle, alpha; myosin heavy chain, polypeptide 7; myosin, heavy chain 6, cardiac muscle, alpha; myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy chain 7B, cardiac muscle, beta; myosin, heavy polypeptide 6, cardiac muscle, alpha; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); myosin, heavy polypeptide 7, cardiac muscle, beta; myosin, heavy polypeptide 7B, cardiac muscle, beta; myosin-6; Myosin-7; myosin-7B; rhabdomyosarcoma antigen MU-RMS-40.7A; slow A MYH14; slow myosin heavy chain; slow myosin heavy chain-beta; slow type myosin heavy chain; SPMD; SPMM; SSS3; type slow/beta myosin heavy chain; U937-associated antigen; Unknown (protein for IMAGE:7985957)